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Index > Protein center > SLC1A3(Gene name) > Human
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  • SLC1A3 (Gene name),
  • Excitatory amino acid transporter 1 (Protein name ),  EAA1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    SLC1A3(EAAT1;GLAST;GLAST1);
    Protein name:
    Excitatory amino acid transporter 1;
    Alternative:
    Solute carrier family 1 member 3;Sodium-dependent glutamate/aspartate transporter 1(GLAST-1);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.
    Subcellular Location:
    Membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    542
    Sequence:
    50:
    MTKSNGEEPK | MGGRMERFQQ | GVRKRTLLAK | KKVQNITKED | VKSYLFRNAF | 
    100:
    VLLTVTAVIV | GTILGFTLRP | YRMSYREVKY | FSFPGELLMR | MLQMLVLPLI | 
    150:
    ISSLVTGMAA | LDSKASGKMG | MRAVVYYMTT | TIIAVVIGII | IVIIIHPGKG | 
    200:
    TKENMHREGK | IVRVTAADAF | LDLIRNMFPP | NLVEACFKQF | KTNYEKRSFK | 
    250:
    VPIQANETLV | GAVINNVSEA | METLTRITEE | LVPVPGSVNG | VNALGLVVFS | 
    300:
    MCFGFVIGNM | KEQGQALREF | FDSLNEAIMR | LVAVIMWYAP | VGILFLIAGK | 
    350:
    IVEMEDMGVI | GGQLAMYTVT | VIVGLLIHAV | IVLPLLYFLV | TRKNPWVFIG | 
    400:
    GLLQALITAL | GTSSSSATLP | ITFKCLEENN | GVDKRVTRFV | LPVGATINMD | 
    450:
    GTALYEALAA | IFIAQVNNFE | LNFGQIITIS | ITATAASIGA | AGIPQAGLVT | 
    500:
    MVIVLTSVGL | PTDDITLIIA | VDWFLDRLRT | TTNVLGDSLG | AGIVEHLSRH | 
    542:
    ELKNRDVEMG | NSVIEENEMK | KPYQLIAQDN | ETEKPIDSET | KM
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    KEGG:
    Pfam:
    UniGene:
    String:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Excitatory amino acid transporter 1
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    E2062r
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    ELISA Kit for Human Excitatory amino acid transporter 1
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    E2062h
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    ELISA Kit for Human Excitatory amino acid transporter 1
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    ELISA Kit for Human Excitatory amino acid transporter 1
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    E2062m
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    CLIA Kit for Human Excitatory amino acid transporter 1
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    U2062r
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    CLIA Kit for Human Excitatory amino acid transporter 1
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    U2062b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Excitatory amino acid transporter 1
    Cat.:
    U2062m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Excitatory amino acid transporter 1
    Cat.:
    U2062h
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    Packing:
    96T
    Polyclonal Antibody for Human Excitatory amino acid transporter 1
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    P2062Rb-m
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    40ug/0.2ml
    Polyclonal Antibody for Human Excitatory amino acid transporter 1
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    Polyclonal Antibody for Human Excitatory amino acid transporter 1
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    P2062Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Excitatory amino acid transporter 1
    Monoclonal Antibody for Human Excitatory amino acid transporter 1
    Monoclonal Antibody for Human Excitatory amino acid transporter 1
    Monoclonal Antibody for Human Excitatory amino acid transporter 1
    Monoclonal Antibody for Human Excitatory amino acid transporter 1
    Protein for Human Excitatory amino acid transporter 1
    Protein for Human Excitatory amino acid transporter 1
    Protein for Human Excitatory amino acid transporter 1
    Protein for Human Excitatory amino acid transporter 1

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning and characterization of a glutamate transporter cDNA from human cerebellum."
      Shashidharan P. , Plaitakis A.
      Biochim. Biophys. Acta1216:161-164(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Cerebellum.
    2. 2.
      "Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex."
      Arriza J.L. , Fairman W.A. , Wendy A. , Wadiche J.I. , Murdoch G.H. , Kavanaugh M.P. , Amara S.G.
      J. Neurosci.14:5559-5569(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Brain cortex.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Brain.
    4. 4.
      "Human high affinity, Na(+)-dependent L-glutamate/L-aspartate transporter GLAST-1 (EAAT-1): gene structure and localization to chromosome 5p11-p12."
      Stoffel W. , Sasse J. , Dueker M. , Mueller R. , Hofmann K.O. , Fink T. , Lichter P.
      FEBS Lett.386:189-193(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      "A novel alternative splicing form of excitatory amino acid transporter 1 is a negative regulator of glutamate uptake."
      Vallejo-Illarramendi A. , Domercq M. , Matute C.
      J. Neurochem.95:341-348(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Cerebellum.
    7. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    9. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    10. 11.
      "Mutation in the glutamate transporter EAAT1 causes episodic ataxia, hemiplegia, and seizures."
      Jen J.C. , Wan J. , Palos T.P. , Howard B.D. , Baloh R.W.
      Neurology65:529-534(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT EA6 ARG-290
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